Denise Morrison
Janssen (Belgium)(BE)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Neuropeptides and Animal Physiology, Analytical Chemistry and Chromatography, Receptor Mechanisms and Signaling, Pesticide Residue Analysis and Safety
Most-Cited Works
- → Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved Pharmacokinetic Profiles(1999)157 cited
- → Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development(2022)141 cited
- → Higher Throughput Bioanalysis by Automation of a Protein Precipitation Assay Using a 96-Well Format with Detection by LC−MS/MS(2000)119 cited
- → Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery(2014)90 cited
- → 2-Aryl Indole NK1 receptor antagonists: optimisation of indole substitution(2001)70 cited
- → The search for novel TRPV1-antagonists: From carboxamides to benzimidazoles and indazolones(2006)65 cited
- → Development and Validation of a Higher-Throughput Equilibrium Dialysis Assay for Plasma Protein Binding(2011)63 cited
- → Ultra‐performance liquid chromatography coupled to time‐of‐flight mass spectrometry for robust, high‐throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data(2006)60 cited
- → Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery(2000)47 cited
- → The Fluorescent Two-Hybrid Assay to Screen for Protein–Protein Interaction Inhibitors in Live Cells: Targeting the Interaction of p53 with Mdm2 and Mdm4(2014)39 cited