Cecilia Y. Cheng
Schrodinger (United States)(US)
Publications by Year
Research Areas
Enzyme Structure and Function, Protein Structure and Dynamics, Protein Kinase Regulation and GTPase Signaling, Phosphodiesterase function and regulation, Computational Drug Discovery Methods
Most-Cited Works
- → PKA-I Holoenzyme Structure Reveals a Mechanism for cAMP-Dependent Activation(2007)358 cited
- → Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for drug design(2007)216 cited
- → Dynamics connect substrate recognition to catalysis in protein kinase A(2010)200 cited
- → Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma(2018)88 cited
- → Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP(2019)41 cited
- → Sensing Domain Dynamics in Protein Kinase A-Iα Complexes by Solution X-ray Scattering(2009)22 cited
- → Repeat Motions and Backbone Flexibility in Designed Proteins with Different Numbers of Identical Consensus Tetratricopeptide Repeats(2006)20 cited
- → Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs(2013)6 cited
- → Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity(2024)5 cited
- → Temporal Response of Plasma Erythropoietin to Hemorrhage in the Ovine Fetus(2002)4 cited