Nigel G. Cooke
Novartis (Switzerland)(CH)Novartis Institutes for BioMedical Research
Publications by Year
Research Areas
Carbohydrate Chemistry and Synthesis, Sphingolipid Metabolism and Signaling, Phytochemical compounds biological activities, Asymmetric Synthesis and Catalysis, Protein Kinase Regulation and GTPase Signaling
Most-Cited Works
- → Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator(2013)165 cited
- → Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer(2005)150 cited
- → The total synthesis of (+)-ionomycin(1990)138 cited
- → Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes(2009)133 cited
- → A Monoselective Sphingosine-1-Phosphate Receptor-1 Agonist Prevents Allograft Rejection in a Stringent Rat Heart Transplantation Model(2006)126 cited
- → Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors(2017)112 cited
- → Identification and synthesis of (Z)-(1′S,3′R,4′S)(–)-2-(3′,4′-epoxy-4′-methylcyclohexyl)-6-methylhepta-2,5-diene, the sex pheromone of the southern green stinkbug, Nezara viridula(L.)(1987)71 cited
- → Total synthesis of (±)-rocaglamide and some aryl analogues(2001)69 cited
- → Structure–Activity Relationship and Pharmacokinetic Studies of Sotrastaurin (AEB071), a Promising Novel Medicine for Prevention of Graft Rejection and Treatment of Psoriasis(2011)39 cited
- → Chemistry of GABAB Modulators(2007)33 cited