Albert Stewart
UCLouvain Saint-Louis Brussels(BE)
Publications by Year
Research Areas
Computational Drug Discovery Methods, Synthesis and biological activity, Lung Cancer Treatments and Mutations, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography
Most-Cited Works
- → Discovery of (10 R )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- 2H -8,4-(metheno)pyrazolo[4,3- h ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations(2014)574 cited
- → WaterLOGSY as a method for primary NMR screening: Practical aspects and range of applicability(2001)552 cited
- → HGF/c-Met Acts as an Alternative Angiogenic Pathway in Sunitinib-Resistant Tumors(2010)309 cited
- → Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes.(1995)256 cited
- → Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20- tetrahydro-7,11-(azeno)pyrido(2',1':2,3)imidazo(4,5-h)(2,5,11) benzoxadiazacyclotetradecine-14-carbonitrile(2014)170 cited
- → Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.(1999)147 cited
- → Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate(2017)135 cited
- → Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)(2017)126 cited
- → Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib(2014)117 cited
- → Structure-Function Analysis of Phosphatidylinositol Transfer Protein Alpha Bound to Human Phosphatidylinositol(2004)95 cited