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Hing L. Sham | doi.page

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Hing L. Sham

University of British Columbia(CA)BC Children's Hospital(CA)

Publications by Year

Research Areas

HIV/AIDS drug development and treatment, Click Chemistry and Applications, HIV Research and Treatment, Chemical Synthesis and Analysis, Protein Kinase Regulation and GTPase Signaling

Most-Cited Works

→ ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease(1998)468 cited
→ Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation(2002)420 cited
→ Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System(2008)267 cited
→ Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy(1998)204 cited
→ Human Serum Attenuates the Activity of Protease Inhibitors toward Wild-Type and Mutant Human Immunodeficiency Virus(1998)177 cited
→ Inhibition and catalytic mechanism of HIV-1 aspartic protease(1996)174 cited

→ In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 1 Variants with Increased Resistance to ABT-378, a Novel Protease Inhibitor(1998)

171 cited

→ Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity(2006)159 cited

→ Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor(2008)139 cited

→ Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores(2001)132 cited