Ph. Coassolo
Roche (Switzerland)(CH)
Publications by Year
Research Areas
Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Analytical Methods in Pharmaceuticals, Neuroscience and Neuropharmacology Research, Epilepsy research and treatment
Most-Cited Works
- → Integration of in Vitro Data into Allometric Scaling to Predict Hepatic Metabolic Clearance in Man: Application to 10 Extensively Metabolized Drugs(1997)179 cited
- → The Use of Human Hepatocytes to Select Compounds Based on Their Expected Hepatic Extraction Ratios in Humans(1997)106 cited
- → Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data(1995)45 cited
- → Interspecies scaling of tolcapone, a new inhibitor of catechol-O-methyltransferase (COMT). Use ofin vitrodata from hepatocytes to predict metabolic clearance in animals and humans(1996)43 cited
- → Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry(1982)30 cited
- → Determination of 7-amino-flunitrazepam (Ro 20-1815) and 7-amino-desmethylflunitrazepam (Ro 5-4650) in plasma by high-performance liquid chromatography and fluorescence detection(1982)28 cited
- → Simultaneous assay of triazolam and its main hydroxy metabolite in plasma and urine by capillary gas chromatography(1983)18 cited
- → Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin, in rat, dog and primates(1996)13 cited
- → The Determination By Means of Capillary Gas Chromatography of the Benzodiazepines-Clobazam, Clonazepam, Diazepam, and Nitrazepam-and Their Principal Metabolites Currently Used In the Treatment of Epilepsy(1989)10 cited
- → Simultaneous Determination of Brotizolam and Its Main Hydroxymetabolite in Plasma by Capillary Gas Chromatography with Double Internal Standardization(1983)7 cited