Ivan Efremov
Fulcrum Therapeutics (United States)(US)NeRRe Therapeutics (United Kingdom)(GB)
Publications by Year
Research Areas
Synthetic Organic Chemistry Methods, Fluorine in Organic Chemistry, Computational Drug Discovery Methods, Synthesis and Reactions of Organic Compounds, Chemical Synthesis and Analysis
Most-Cited Works
- → Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor(2012)421 cited
- → Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S )-2,2-Difluorocyclopropyl)((1 R ,5 S )-3-(2-((1-methyl-1 H -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)(2018)170 cited
- → A Convenient Method for Removing All Highly-Colored Byproducts Generated during Olefin Metathesis Reactions(2000)147 cited
- → Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors(2011)105 cited
- → Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor(2018)95 cited
- → Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design(2012)63 cited