Tobias Gabriel
Technical University of Darmstadt(DE)
Publications by Year
Research Areas
Melanoma and MAPK Pathways, Synthesis and biological activity, Cancer-related Molecular Pathways, Synthesis of Tetrazole Derivatives, Epigenetics and DNA Methylation
Most-Cited Works
- → Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1(2018)436 cited
- → Pathway to the Clinic: Inhibition of P38 MAP Kinase. A Review of Ten Chemotypes Selected for Development(2005)149 cited
- → Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis(2014)107 cited
- → Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy(2017)101 cited
- → Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase(2011)74 cited
- → The chromium—Reformatsky reaction: Asymmetric synthesis of the aldol fragment of the cytotoxic epothilons from 3-(2-bromoacyl)-2-oxazolidinones(1997)64 cited
- → Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase(2016)57 cited
- → Chromium(II)-Mediated Reformatsky Reactions of Carboxylic Esters with Aldehydes(1997)46 cited
- → The chromium-Reformatsky reaction: anti-selective Evans-type aldol reactions with excellent inverse induction at ambient temperature(1997)38 cited
- → 3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: Design and development to a highly selective lead(2011)27 cited