John E. Souness
Publications by Year
Research Areas
Phosphodiesterase function and regulation, Asthma and respiratory diseases, Adenosine and Purinergic Signaling, Phenothiazines and Benzothiazines Synthesis and Activities, Cholinesterase and Neurodegenerative Diseases
Most-Cited Works
- → Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors(2000)245 cited
- → Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases(1997)187 cited
- → Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer(1996)115 cited
- → Anti‐inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor(1994)109 cited
- → Characterization of guinea-pig eosinophil phosphodiesterase activity(1991)105 cited
- → The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy(2001)90 cited
- → Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY‐5445, vinpocetine and 1‐methyl‐3‐isobutyl‐8‐(methylamino)xanthine(1989)81 cited
- → Inhibition of pig aortic smooth muscle cell DNA synthesis by selective type III and type IV cyclic AMP phosphodiesterase inhibitors(1992)77 cited
- → An Algorithm-Directed Two-Component Library Synthesized Via Solid-Phase Methodology Yielding Potent and Orally Bioavailable p38 MAP Kinase Inhibitors(2002)73 cited
- → The effect of cyclic AMP and cyclic GMP phosphodiesterase inhibitors on the superoxide burst of guinea‐pig peritoneal macrophages(1993)62 cited