Jean‐Jacques Lohmann
AstraZeneca (France)(FR)
Publications by Year
Research Areas
PI3K/AKT/mTOR signaling in cancer, Coordination Chemistry and Organometallics, Protein Kinase Regulation and GTPase Signaling, Cell Adhesion Molecules Research, Catalytic Alkyne Reactions
Most-Cited Works
- → Discovery of (R)-8-(1-(3,5-Difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the Treatment of PTEN-Deficient Cancers(2014)86 cited
- → Alkylation of the isoquinoline skeleton in the 1-position(1983)82 cited
- → Cyclopropenes as Vinylcarbenoids:Intermolecular Carbene‐Addition Reactions of Sulfinyl‐ and Sulfonylcyclopropenes at Room Temperature(1977)38 cited
- → Lithiated N‐pivaloyl‐tetrahydroisoquinoline—a Supernuclephile(1981)33 cited
- → Cyclopropene als Vinylcarbenoide: intermolekulare Carben‐Additionsreaktionen von Sulfinyl‐ und Sulfonyl‐cyclopropenen bei Raumtemperatur(1977)16 cited
- → Lithiiertes N‐Pivaloyl‐tetrahydroisochinolin – ein Supernucleophil(1981)13 cited
- → Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 1(2012)9 cited
- → Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 2(2012)9 cited
- → Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours(2016)7 cited
- → Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours(2017)4 cited