Michael A. Ackley
Sage Therapeutics (United States)(US)
Publications by Year
Research Areas
Neuroscience and Neuropharmacology Research, Receptor Mechanisms and Signaling, Pain Mechanisms and Treatments, Ion channel regulation and function, Neuropeptides and Animal Physiology
Most-Cited Works
- → Nucleoside transporters: from scavengers to novel therapeutic targets(2006)280 cited
- → Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator(2020)121 cited
- → Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1 H -pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid) A Receptor(2017)120 cited
- → Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism(2016)76 cited
- → A cellular mechanism for the antinociceptive effect of a kappa opioid receptor agonist(2001)59 cited
- → Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1(2003)58 cited
- → Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid) A Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C-21(2015)53 cited
- → Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors(2019)49 cited
- → SAGE-718: A First-in-ClassN-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment(2022)41 cited