A. Shao
Roche (United States)(US)
Publications by Year
Research Areas
Cytokine Signaling Pathways and Interactions, Quinazolinone synthesis and applications, Melanoma and MAPK Pathways, Rheumatoid Arthritis Research and Therapies, Synthesis and biological activity
Most-Cited Works
- → 3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models(2012)66 cited
- → Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors(2013)32 cited
- → Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead(2012)27 cited
- → Scaffold hopping towards potent and selective JAK3 inhibitors: Discovery of novel C-5 substituted pyrrolopyrazines(2014)22 cited
- → Discovery of a novel series of 4-quinolone JNK inhibitors(2012)19 cited
- → Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): Optimization for JNK potency and physicochemical properties(2013)18 cited
- → JAK3 kinase domain in complex with 2-Phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-cyclopropyl-ethyl)-amide(2012)
- Discovery of a series of novel 5H-pyrrolo[2,3<em>-b]</em>pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors(2013)
- → Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(4-Methanesulfonyl-piperidin-1-yl)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexan(2013)
- → JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide(2012)