Mark T. Goulet
Merck & Co., Inc., Rahway, NJ, USA (United States)(US)
Publications by Year
Research Areas
Chemical Synthesis and Analysis, Cannabis and Cannabinoid Research, Hypothalamic control of reproductive hormones, Neurotransmitter Receptor Influence on Behavior, Receptor Mechanisms and Signaling
Most-Cited Works
- → [18F]MK-9470, a positron emission tomography (PET) tracer forin vivohuman PET brain imaging of the cannabinoid-1 receptor(2007)313 cited
- → “The role of melanocortins in body weight regulation: opportunities for the treatment of obesity”(2002)138 cited
- → Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor(2003)137 cited
- → Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity(2006)122 cited
- → Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors(2011)106 cited
- → Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1 S,2 S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents(2007)101 cited
- → Asymmetric Synthesis of Chiral, Nonracemic Trifluoromethyl-Substituted Piperidines and Decahydroquinolines(1999)75 cited
- → A convergent synthesis of ( S )-β-methyl-2-aryltryptamine based gonadotropin releasing hormone antagonists(2001)73 cited
- → Application of the two-directional chain synthesis strategy to the first stereochemical assignment of structure to members of the skipped-polyol polyene macrolide class: mycoticin A and B(1987)70 cited
- → The role of melanocortins in body weight regulation: opportunities for the treatment of obesity(2002)64 cited