Michel Vautier

Publications by Year

Research Areas

Quinazolinone synthesis and applications, HER2/EGFR in Cancer Research, Cell Adhesion Molecules Research, Chemical Synthesis and Analysis, Fluorine in Organic Chemistry

Most-Cited Works

• → Discovery of (R)-8-(1-(3,5-Difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the Treatment of PTEN-Deficient Cancers(2014)86 cited
• → Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers(2015)35 cited
• → New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors(2005)28 cited
• → A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase(2007)18 cited
• → Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase(2008)10 cited
• → Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 1(2012)9 cited
• → Structure–activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 2(2012)9 cited
• → Facile preparation of alkoxybenzoxazoles via direct SNAr on the benzoxazole ring(2009)6 cited
• → Abstract 2830: Discovery of AZD8835, a potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of PIK3CA-dependent cancers(2015)1 cited
• → New Heterocyclic Analogues of 4‐(2‐Chloro‐5‐methoxyanilino)quinazolines as Potent and Selective c‐Src Kinase Inhibitors.(2006)