Michael Mortimore
Vertex Pharmaceuticals (United Kingdom)(GB)Vertex Pharmaceuticals (United States)(US)
Publications by Year
Research Areas
Alkaloids: synthesis and pharmacology, Chemical synthesis and alkaloids, Synthetic Organic Chemistry Methods, Microtubule and mitosis dynamics, Cancer-related Molecular Pathways
Most-Cited Works
- → Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents(2011)258 cited
- → Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents(2009)178 cited
- → Biogenetically Inspired Approach to the Strychnos Alkaloids. Concise Syntheses of (±)-Akuammicine and (±)-Strychnine(2001)159 cited
- → Characterization of a selective and potent antagonist of human P2X7receptors, AZ11645373(2006)130 cited
- → The discovery of the potent aurora inhibitor MK-0457 (VX-680)(2009)99 cited
- → Unified strategy for synthesis of indole and 2-oxindole alkaloids(1991)87 cited
- → A Biomimetic Approach to the Strychnos Alkaloids. A Novel, Concise Synthesis of (±)-Akuammicine and a Route to (±)-Strychnine(1996)59 cited
- → Novel P2X7 receptor antagonists(2003)58 cited
- → Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X7Receptor Antagonists/Interleukin-1β Inhibitors(2007)58 cited
- → VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis(2009)43 cited