Karen O’Rourke
Fondation pour la Recherche Stratégique(FR)Laing O'Rourke (United Kingdom)(GB)Artistic Realization Technologies(US)
Publications by Year
Research Areas
Cell death mechanisms and regulation, Ubiquitin and proteasome pathways, Angiogenesis and VEGF in Cancer, Protease and Inhibitor Mechanisms, NF-κB Signaling Pathways
Most-Cited Works
- → Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling(2015)3,565 cited
- → FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex(1996)3,049 cited
- → Cryopyrin activates the inflammasome in response to toxins and ATP(2006)3,012 cited
- → FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis(1995)2,419 cited
- → Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase(1995)2,390 cited
- → De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling(2004)1,816 cited