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Andrew Siwkowski | doi.page

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Andrew Siwkowski

Vanderbilt University(US)Ionis Pharmaceuticals (United States)(US)Antisense Therapeutics (Australia)(AU)

Publications by Year

Research Areas

DNA and Nucleic Acid Chemistry, RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, RNA and protein synthesis mechanisms, CRISPR and Genetic Engineering

Most-Cited Works

→ Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals(2006)450 cited
→ Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals(2008)264 cited
→ Inhibition of HPV-16 E6/E7 immortalization of normal keratinocytes by hairpin ribozymes(1998)95 cited
→ Antisense Oligonucleotide Blockade of Tumor Necrosis Factor-α in Two Murine Models of Colitis(2003)90 cited
→ Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate(2006)89 cited
→ An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA(2010)85 cited

→ Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2′-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN(2009)

82 cited

→ Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-(N-Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′-O,4′-C-Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models(2010)72 cited

→ Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing(2004)50 cited

→ Catalytic Properties of Hairpin Ribozymes Derived from Chicory Yellow Mottle Virus and Arabis Mosaic Virus Satellite RNAs(1995)48 cited