Peter Lockey
Charles River Laboratories (United Kingdom)(GB)
Publications by Year
Research Areas
Receptor Mechanisms and Signaling, Estrogen and related hormone effects, Retinoids in leukemia and cellular processes, Histone Deacetylase Inhibitors Research, Drug Transport and Resistance Mechanisms
Most-Cited Works
- → Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator(2013)117 cited
- → Histone Deacetylase Inhibitor Trichostatin A Represses Estrogen Receptor α-Dependent Transcription and Promotes Proteasomal Degradation of Cyclin D1 in Human Breast Carcinoma Cell Lines(2004)113 cited
- → Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action(2014)82 cited
- → A Virtual Screening Approach to Finding Novel and Potent Antagonists at the Melanin-Concentrating Hormone 1 Receptor(2004)79 cited
- → Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc(2013)62 cited
- → Discovery of 1-{4-[3-Fluoro-4-((3 S ,6 R )-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist(2015)59 cited
- → An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer(2015)51 cited
- → 1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity(2008)49 cited
- → Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists(2014)49 cited
- → Structure–activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists(2004)42 cited