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Giles A. Brown | doi.page

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Giles A. Brown

Amicus Therapeutics (United Kingdom)(GB)Mission Therapeutics (United Kingdom)(GB)Granta Design (United Kingdom)(GB)

Publications by Year

Research Areas

Receptor Mechanisms and Signaling, Synthesis of β-Lactam Compounds, Synthesis and Catalytic Reactions, Neuroscience and Neuropharmacology Research, Neuropeptides and Animal Physiology

Most-Cited Works

→ Structural insight into allosteric modulation of protease-activated receptor 2(2017)248 cited
→ Small molecule AZD4635 inhibitor of A_2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity(2020)97 cited
→ Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals(2018)93 cited
→ From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease(2021)89 cited
→ Sequenced Reactions with Samarium(II) Iodide. Sequential Intramolecular Barbier Cyclization/Grob Fragmentation for the Synthesis of Medium-Sized Carbocycles(2001)77 cited
→ Structure‐Based and Fragment‐Based GPCR Drug Discovery(2013)72 cited

→ Recent Developments in Therapeutic Peptides for the Glucagon-like Peptide 1 and 2 Receptors(2019)

55 cited

→ Targeting adenosine A_2A receptor antagonism for treatment of cancer(2018)54 cited

→ Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target(2018)49 cited

→ Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits(2021)43 cited