Daniel F. Ortwine
Publications by Year
Research Areas
Synthesis and biological activity, Computational Drug Discovery Methods, Quinazolinone synthesis and applications, Synthesis and Biological Evaluation, Synthesis and Characterization of Heterocyclic Compounds
Most-Cited Works
- → Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability(2013)406 cited
- → Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist(2015)324 cited
- → Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development(2018)241 cited
- → Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects(2007)209 cited
- → Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus(1991)183 cited
- → Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations(2016)133 cited
- → Novel Series of Achiral, Low Molecular Weight, and Potent HIV-1 Protease Inhibitors(1994)132 cited
- → GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer(2021)132 cited
- → 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution(2006)107 cited
- → Substituted 2-Benzothiazolamines as Sodium Flux Inhibitors: Quantitative Structure-Activity Relationships and Anticonvulsant Activity(1994)107 cited