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R. Derike Smiley | doi.page

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R. Derike Smiley

Pennsylvania State University(US)Howard Hughes Medical Institute(US)Duke University(US)Duke Medical Center(US)Duke University Hospital(US)

Publications by Year

Research Areas

Enzyme Structure and Function, RNA and protein synthesis mechanisms, Biochemical and Molecular Research, DNA and Nucleic Acid Chemistry, Advanced Fluorescence Microscopy Techniques

Most-Cited Works

→ Single Molecule Studies of Enzyme Mechanisms(2006)157 cited
→ Conformation Coupled Enzyme Catalysis: Single-Molecule and Transient Kinetics Investigation of Dihydrofolate Reductase(2005)103 cited
→ Preliminary Evidence that Degradation of Aflatoxin B1 by Flavobacterium aurantiacum is Enzymatic(2000)95 cited
→ Single-Molecule Investigation of the T4 Bacteriophage DNA Polymerase Holoenzyme: Multiple Pathways of Holoenzyme Formation(2006)38 cited
→ Role of S65, Q67, I68, and Y69 Residues in Homotetrameric R67 Dihydrofolate Reductase(2001)29 cited
→ Role of Ionic Interactions in Ligand Binding and Catalysis of R67 Dihydrofolate Reductase(2003)27 cited

→ Calorimetric Studies of Ligand Binding in R67 Dihydrofolate Reductase(2005)

23 cited

→ One site fits both: A model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme(2001)22 cited

→ Defining the Binding Site of Homotetrameric R67 Dihydrofolate Reductase and Correlating Binding Enthalpy with Catalysis(2004)20 cited

→ Breaking Symmetry: Mutations Engineered into R67 Dihydrofolate Reductase, aD₂Symmetric Homotetramer Possessing a Single Active Site Pore(2002)19 cited