Janet Sim
Novartis (United States)(US)
Publications by Year
Research Areas
Microbial Natural Products and Biosynthesis, Biochemical and Molecular Research, Enzyme Structure and Function, Genomics and Phylogenetic Studies, DNA Repair Mechanisms
Most-Cited Works
- → Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation(2013)161 cited
- → Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors(2014)41 cited
- → Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors(2017)40 cited
- → Identification of Novel Small-Molecule Inhibitors for Human Transketolase by High-Throughput Screening with Fluorescent Intensity (FLINT) Assay(2004)37 cited
- → Mutation of N304 to Leucine in Streptomyces clavuligerus Deacetoxycephalosporin C Synthase Creates an Enzyme with Increased Penicillin Analogue Conversion(2001)33 cited
- → Mutational Evidence Supporting the Involvement of Tripartite Residues His183, Asp185, and His243 inStreptomyces clavuligerusDeacetoxycephalosporin C Synthase for Catalysis(2000)20 cited
- → Amino acid substitutions affecting protein solubility: high level expression of Streptomyces clavuligerus isopenicillin N synthase in Escherichia coli(1999)20 cited
- → Functional analysis of a conserved aspartate D218 in Cephalosporium acremonium isopenicillin N synthase(2006)16 cited
- → In vitro conversion of penicillin G and ampicillin by recombinant Streptomyces clavuligerus NRRL 3585 deacetoxycephalosporin C synthase(2001)14 cited
- → High-level soluble expression, purification and characterization of active human midkine from Escherichia coli(2009)11 cited