Machiko Irie
Publications by Year
Research Areas
NF-κB Signaling Pathways, Chemical Synthesis and Analysis, Monoclonal and Polyclonal Antibodies Research, Melanoma and MAPK Pathways, Click Chemistry and Applications
Most-Cited Works
- → Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor(2023)135 cited
- → Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases(2017)104 cited
- → Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets(2023)89 cited
- → Crystal structure of the halotolerant γ‐glutamyltranspeptidase from Bacillus subtilis in complex with glutamate reveals a unique architecture of the solvent‐exposed catalytic pocket(2010)58 cited
- → Crystal Structures of γ-Glutamyltranspeptidase in Complex with Azaserine and Acivicin: Novel Mechanistic Implication for Inhibition by Glutamine Antagonists(2008)47 cited
- → Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors(2012)29 cited
- → Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)(2016)14 cited
- → Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease(2023)13 cited
- → Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display(2024)8 cited
- → Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD)(2016)7 cited