Toshiharu Yoshino
Daiichi-Sankyo (Japan)(JP)
Publications by Year
Research Areas
Synthetic Organic Chemistry Methods, Blood Coagulation and Thrombosis Mechanisms, Cancer Treatment and Pharmacology, Oxidative Organic Chemistry Reactions, Marine Sponges and Natural Products
Most-Cited Works
- → Synthetic studies of huperzine A and its fluorinated analogues. 1. Novel asymmetric syntheses of an enantiomeric pair of huperzine A(1998)86 cited
- → Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 Binding Element(2004)70 cited
- → A Total Synthesis of Xestodecalactone A and Proof of Its Absolute Stereochemistry: Interesting Observations on Dienophilic Control with 1,3-Disubstituted Nonequivalent Allenes(2006)61 cited
- → Total synthesis of natural (+)-FR900482. 2. Efficient syntheses of the aromatic and the optically active aliphatic fragments(1996)59 cited
- → Total synthesis of an enantiomeric pair of FR900482. 1. Synthetic and end-game strategies(1997)51 cited
- → A novel enantioselective synthesis of the key intermediate of (−)-huperzine a employing asymmetric palladium-catalyzed bicycloannulation(1997)50 cited
- → Total synthesis of an enantiomeric pair of FR900482. 2. Syntheses of the aromatic and the optically active aliphatic segments(1997)43 cited
- → Total synthesis of natural (+)-FR900482. 1. Synthetic and end-game strategies(1996)42 cited
- → Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa(2008)42 cited
- → Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties(2009)42 cited