M. Brawner Floyd

Publications by Year

Research Areas

Quinazolinone synthesis and applications, HER2/EGFR in Cancer Research, Inflammatory mediators and NSAID effects, Chemical Synthesis and Analysis, Chemical Synthesis and Reactions

Most-Cited Works

• → A quantitative analysis of kinase inhibitor selectivity(2008)2,427 cited
• → A small molecule–kinase interaction map for clinical kinase inhibitors(2005)1,903 cited
• → Antitumor Activity of HKI-272, an Orally Active, Irreversible Inhibitor of the HER-2 Tyrosine Kinase(2004)630 cited
• → Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases(2005)554 cited
• → Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity(2005)295 cited
• → Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)(2002)263 cited
• → 4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors(2000)209 cited
• → Prostaglandins and congeners. 20. Synthesis of prostaglandins via conjugate addition of lithium trans-1-alkenyltrialkylalanate reagents. A novel reagent for conjugate 1,4-additions(1979)169 cited
• → The oxidation of acetophenones to arylglyoxals with aqueous hydrobromic acid in dimethyl sulfoxide(1985)128 cited
• → Activation State-Dependent Binding of Small Molecule Kinase Inhibitors: Structural Insights from Biochemistry(2010)123 cited