Steve Tam

Publications by Year

Research Areas

Protein Kinase Regulation and GTPase Signaling, Inflammatory mediators and NSAID effects, Adenosine and Purinergic Signaling, Synthesis and biological activity, Coagulation, Bradykinin, Polyphosphates, and Angioedema

Most-Cited Works

• → Indole Cytosolic Phospholipase A₂α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib(2008)88 cited
• → Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α₂α(2007)79 cited
• → Inhibition of Cytosolic Phospholipase A₂α: Hit to Lead Optimization(2005)76 cited
• → Structure–activity studies of a series of dipyrazolo[3,4-b:3′,4′-d]pyridin-3-ones binding to the immune regulatory protein B7.1(2003)44 cited
• → Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties(2009)31 cited
• → Potential therapeutic uses of phospholipase A₂inhibitors(2004)29 cited
• → Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy(2007)28 cited
• → Combination of disopyramide and mexiletine for better tolerance and additive effects for treatment of ventricular arrhythmias(1989)24 cited
• → 1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors(2006)23 cited
• → Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A₂α Inhibitors(2009)18 cited