Bruce A. Malcolm
Janssen (Belgium)(BE)
Publications by Year
Research Areas
Hepatitis C virus research, Monoclonal and Polyclonal Antibodies Research, Hepatitis B Virus Studies, HIV/AIDS drug development and treatment, Viral Infections and Immunology Research
Most-Cited Works
- → Two-Stage PCR Protocol Allowing Introduction of Multiple Mutations, Deletions and Insertions Using QuikChange TM Site-Directed Mutagenesis(1999)600 cited
- → SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells(2006)316 cited
- → Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases(1994)305 cited
- → Discovery of (1 R ,5 S )- N -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( S )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( S )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection(2006)278 cited
- → Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing(1990)228 cited
- → The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA(2003)176 cited
- → Site-directed mutagenesis of the catalytic residues Asp-52 and Glu-35 of chicken egg white lysozyme.(1989)175 cited
- → The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition(1997)163 cited
- → Structural and thermodynamic analysis of compensating mutations within the core of chicken egg white lysozyme.(1992)154 cited
- → Two-Stage Polymerase Chain Reaction Protocol Allowing Introduction of Multiple Mutations, Deletions, and Insertions, Using QuikChangeTM Site-Directed Mutagenesis(2002)134 cited