R.H.A. Folmer
Publications by Year
Research Areas
Bacteriophages and microbial interactions, Protein Structure and Dynamics, Enzyme Structure and Function, Computational Drug Discovery Methods, DNA and Nucleic Acid Chemistry
Most-Cited Works
- → Structure of the PPARα and -γ Ligand Binding Domain in Complex with AZ 242; Ligand Selectivity and Agonist Activation in the PPAR Family(2001)324 cited
- → Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency(2007)211 cited
- → Fragment screening to predict druggability (ligandability) and lead discovery success(2011)200 cited
- → Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation(2007)148 cited
- → Exploitation of structural and regulatory diversity in glutamate racemases(2007)138 cited
- → An Integrated Approach to Fragment-Based Lead Generation:Philosophy, Strategy and Case Studies from AstraZenecas Drug Discovery Programmes(2007)127 cited
- → Bivalent Ligands for Protein Degradation in Drug Discovery(2019)114 cited
- → Floating stereospecific assignment revisited: Application to an 18 kDa protein and comparison with J-coupling data(1997)110 cited
- → A Model of the Complex between Single-stranded DNA and the Single-stranded DNA Binding Protein Encoded by Gene V of Filamentous Bacteriophage M13(1994)96 cited
- → Overcoming the ambiguity problem encountered in the analysis of nuclear Overhauser magnetic resonance spectra of symmetric dimer proteins(1993)77 cited