Xin Huang
Chinese Academy of Medical Sciences & Peking Union Medical College(CN)
Publications by Year
Research Areas
Cancer-related Molecular Pathways, Microtubule and mitosis dynamics, Ubiquitin and proteasome pathways, Click Chemistry and Applications, Protein Kinase Regulation and GTPase Signaling
Most-Cited Works
- → AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies(2018)409 cited
- → Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development(2014)291 cited
- → Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction(2012)167 cited
- → Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors(2013)84 cited
- → Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction(2014)83 cited
- → Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity(2006)67 cited
- → Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase(2008)64 cited
- → Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres(2014)54 cited
- → Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR(2007)48 cited
- → Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction(2014)47 cited