Synthesis of Enantiopure γ‐Lactones via a RuPHOX‐Ru Catalyzed Asymmetric Hydrogenation of γ‐Keto Acids
Advanced Synthesis & Catalysis2018Vol. 361(5), pp. 1146–1153
Citations Over TimeTop 23% of 2018 papers
Abstract
Abstract A RuPHOX−Ru catalyzed asymmetric hydrogenation of γ‐keto acids has been developed, affording the corresponding enantiopure γ‐lactones in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 10000 S/C) under the indicated reaction conditions and the resulting products can be transformed to several enantiopure building blocks, biologically active compounds and enantiopure drugs. magnified image
Related Papers
- → Synthesis of Enantiopure γ‐Lactones via a RuPHOX‐Ru Catalyzed Asymmetric Hydrogenation of γ‐Keto Acids(2018)26 cited
- → Synthesis of Enantiopure o-Hydroxybenzylamines by Stereoselective Reduction of 2-Imidoylphenols: Application in the Catalytic Enantioselective Addition of Diethylzinc to Aldehydes(1999)3 cited
- → Enantiopure Guanidine Bases For Enantioselective Enone Epoxidations: 1, Acyclic Guanidines(2003)1 cited
- → ChemInform Abstract: Efficacious and Rapid Metal‐ and Solvent‐Free Synthesis of Enantiopure Oxazolines.(2015)
- → ChemInform Abstract: Chiral Pyridin‐3‐ones and Pyridines: Syntheses of Enantiopure 2,4‐Disubstituted 6‐Hydroxy‐1,6‐dihydro‐2H‐pyridin‐3‐ones, 2,3‐Disubstituted 4‐Iodopyridines, and Enantiopure 2,3‐Disubstituted 4‐Pyridinemethanols.(2012)