Female sex hormones suppress development of collagen‐induced arthritis in mice
Arthritis & Rheumatism1986Vol. 29(12), pp. 1501–1509
Citations Over TimeTop 10% of 1986 papers
Abstract
We have previously reported that male DBA/1 mice are more susceptible to collagen-induced arthritis than are females. Here we report that oophorectomy makes female mice as susceptible to collagen arthritis as are normal males. Induction of collagen-induced arthritis in mice is a T cell-dependent process. The role of female sex hormones in modulating T cell-dependent autoimmune diseases is discussed.
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