Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3‐Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon‐Positive Primary Sjögren's Syndrome
Arthritis & Rheumatology2016Vol. 68(7), pp. 1688–1699
Citations Over TimeTop 17% of 2016 papers
Naomi I. Maria, Cornelia G van Helden-Meeuwsen, Zana Brkić, Sandra M. J. Paulissen, Eline C. Steenwijk, Virgil A. S. H. Dalm, Paul Van Daele, P. Martin van Hagen, Frans G. M. Kroese, Joël A. G. van Roon, Andrew Harkin, Willem A. Dik, Hemmo A. Drexhage, Erik Lubberts, Marjan A. Versnel
Abstract
These findings demonstrate enhanced IDO activity in conjunction with increased percentages of CD25(high) FoxP3+ Treg cells in primary SS patients who carry the IFN signature. In addition, IFN-positive patients with primary SS exhibit an imbalanced kynurenine pathway, with evidence of a shift toward potentially more proapoptotic and neurotoxic metabolites. Intervening in these IFN- and IDO-induced immune system imbalances may offer a new array of possibilities for therapeutic interventions in patients with primary SS.
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