Are there specific readers of oxidized 5‐methylcytosine bases?
BioEssays2016Vol. 38(10), pp. 1038–1047
Citations Over TimeTop 10% of 2016 papers
Abstract
5-methylcytosine (5mC) was long thought to be the only enzymatically created modified DNA base in mammalian cells. The discovery of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine as reaction products of the TET family 5mC oxidases has prompted extensive searches for proteins that specifically bind to these oxidized bases. However, only a few of such "reader" proteins have been identified and verified so far. In this review, we discuss potential biological functions of oxidized 5mC as well as the role the presumed reader proteins may play in interpreting the genomic signals of 5mC oxidation products.
Related Papers
- → TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine(2013)50 cited
- → Are there specific readers of oxidized 5‐methylcytosine bases?(2016)38 cited
- → Determination of trace amounts of 5-methylcytosine in DNA by reverse-phase high-performance liquid chromatography(1987)66 cited
- A new sight of epigenetics——5-hydroxymethylcytosine(2012)
- → Selective Chemical Labeling and Sequencing of 5-Hydroxymethylcytosine in DNA at Single-Base Resolution(2021)