Application of hydrogel microneedles in the oral cavity

Citations Over TimeTop 14% of 2024 papers

Abstract

Microneedles are a transdermal drug delivery system in which the needle punctures the epithelium to deliver the drug directly to deep tissues, thus avoiding the influence of the first-pass effect of the gastrointestinal tract and minimizing the likelihood of pain induction. Hydrogel microneedles are microneedles prepared from hydrogels that have good biocompatibility, controllable mechanical properties, and controllable drug release and can be modified to achieve environmental control of drug release in vivo. The large epithelial tissue in the oral cavity is an ideal site for drug delivery via microneedles. Hydrogel microneedles can overcome mucosal hindrances to delivering drugs to deep tissues; this prevents humidity and a highly dynamic environment in the oral cavity from influencing the efficacy of the drugs and enables them to obtain better therapeutic effects. This article analyzes the materials and advantages of common hydrogel microneedles and reviews the application of hydrogel microneedles in the oral cavity.

Related Papers

• → Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications(2018)289 cited
• → Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs(2015)204 cited
• → Construction of Tough, in Situ Forming Double-Network Hydrogels with Good Biocompatibility(2016)81 cited
• → The effects of chemical crosslinking manners on the physical properties and biocompatibility of collagen type I/hyaluronic acid composite hydrogels(2020)53 cited
• → Injectable microgel–hydrogel composites “plum pudding gels”: new system for prolonged drug delivery(2019)17 cited