Determination of ephedrine and related compounds in pharmaceutical preparations by ion chromatography with direct conductivity detection
Biomedical Chromatography2005Vol. 19(4), pp. 266–271
Citations Over Time
Abstract
An ion chromatographic method with conductivity detection for the simultaneous determination of ephedrine, pseudoephedrine and norephedrine was developed. A mixture of 2.0 mmol/L HNO3 and 2% (v/v) acetonitrile was used as eluent. The three ephedrine-like compounds were separated and determined within 20 min. The linear ranges were 0.08-50 microg/mL for ephedrine, 0.08-40 microg/mL for pseudoephedrine and 0.06-40 microg/mL for norephedrine. The detection limits were 0.03 microg/mL for ephedrine and pseudoephedrine, and 0.02 microg/mL for norephedrine. The method has been applied successfully to the determination of these sympathomimetics in pharmaceutical preparations and in Ephedra herbs.
Related Papers
- → Determination of ephedrine and related compounds in pharmaceutical preparations by ion chromatography with direct conductivity detection(2005)10 cited
- → Separation and determination of ephedrine and pseudoephedrine in Ephedrae Herba by CZE modified with a Cu(II)–L‐lysine complex(2008)17 cited
- → Urinary Elimination of Ephedrines Following Administration of the Traditional Chinese Medicine Preparation Kakkon-to(2008)13 cited
- → Determination of ephedrine and pseudoephedrine in Chinese herbal preparations by capillary electrophoresis(1993)46 cited
- Content Determination of Ephedrine and Pseudoephedrine in Mafu Capsules (Herba Ephedrae, Radix Aconiti Praeparata, etc.) by High Performance Capillary Electrophoresis(1999)