Synthesis and Activity of Carbazole Derivatives Against Mycobacterium tuberculosis
ChemMedChem2006Vol. 1(8), pp. 812–815
Citations Over TimeTop 13% of 2006 papers
Taylor A. Choi, Regina Czerwonka, Wolfgang Fröhner, Micha P. Krahl, Kethiri R. Reddy, Scott G. Franzblau, Hans‐Joachim Knölker
Abstract
A series of carbazole derivatives was tested for inhibition of Mycobacterium tuberculosis growth and a mammalian cell line. Among several compounds with anti-TB activity, carbazoles A and B showed MIC values of 4.0 μg mL−1 (8 μM) and 2.2 μg mL−1 (9 μM) respectively, against M. tuberculosis and were relatively nontoxic for the mammalian cell line.
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