Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV‐A Irradiation of 5‐Methoxypsoralen
ChemMedChem2010Vol. 5(9), pp. 1506–1512
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Alessia Salvador, Stefano Dall’Acqua, Manlio Sutera Sardo, Sergio Caffieri, Daniela Vedaldi, Francesco Dall’Acqua, Monica Borgatti, Cristina Zuccato, Nicoletta Bianchi, Roberto Gambari
Abstract
Induction of terminal erythroid differentiation can be an efficient strategy to inhibit proliferation of chronic myelogenous leukemia cells. Psoralens, well-known photo-chemotherapeutic agents, were found to be efficient at inducing erythroid differentiation of K562 cells, an in vitro cell line isolated from the pleural effusion of a patient with chronic myelogenous leukemia in blast crisis. The effects of crude pre-irradiated solutions of 5-methoxypsoralen on erythroid differentiation of human leukemic K-562 cells were evaluated. The major photoproduct was characterized and analyzed, and it was found to induce erythroid differentiation of K562 cells and inhibit NF-kappaB/DNA interactions.
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