Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
Clinical and Translational Medicine2021Vol. 11(3), pp. e372–e372
Citations Over TimeTop 10% of 2021 papers
Premranjan Kumar, Chun Liu, Jean W. Hsu, Shaji Chacko, Charles G. Minard, Farook Jahoor, Rajagopal V. Sekhar
Abstract
GlyNAC supplementation for 24-weeks in OA was well tolerated and lowered OxS, corrected intracellular GSH deficiency and mitochondrial dysfunction, decreased inflammation, insulin-resistance and endothelial dysfunction, and genomic-damage, and improved strength, gait-speed, cognition, and body composition. Supplementing GlyNAC in aging humans could be a simple and viable method to promote health and warrants additional investigation.
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