Lactobacillus lactis and Pediococcus pentosaceus‐driven reprogramming of gut microbiome and metabolome ameliorates the progression of non‐alcoholic fatty liver disease
Clinical and Translational Medicine2021Vol. 11(12), pp. e634–e634
Citations Over TimeTop 1% of 2021 papers
Jeong Seok Yu, Gi Soo Youn, Jieun Choi, Chang‐Ho Kim, Byung‐Yong Kim, Seung‐Jo Yang, Jehee Lee, Tae‐Sik Park, Byoung Kook Kim, Yeon Bee Kim, Seong Woon Roh, Byeong Hyun Min, Hyojin Park, Sang Jun Yoon, Na Young Lee, Ye Rin Choi, Hyeong Seob Kim, Haripriya Gupta, Hotaik Sung, Sang Hak Han, Ki Tae Suk, Do Yup Lee
Abstract
NAFLD progression was robustly associated with metabolic dys-regulations in the SCFAs, bile acid and indole compounds, and NAFLD can be accurately diagnosed using the metabolites. L. lactis and P. pentosaceus ameliorate NAFLD progression by modulating gut metagenomic and metabolic environment, particularly tryptophan pathway, of the gut-liver axis.
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