Passerini Reaction to Access α‐Hydroxy Amides by Facile Decarbonylation/Decarboxylation of Oxalic Acid
European Journal of Organic Chemistry2022Vol. 2022(48)
Citations Over Time
Abstract
Abstract α‐Hydroxy amides are an essential class of compounds found in natural products and bioactive molecules of drug candidates. Herein we report a facile and direct approach to these compounds through oxalic acid decarbonylation/decarboxylation during the Passerini three‐component reaction (P‐3CR) under solvent‐free conditions with microwave heating. This very convenient methodology provides the title compounds through a possible concerted intramolecular decarbonylation/decarboxylation from the α‐acyloxy amide intermediate.
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