Successful liver transplantation in an infant with stage 4S(M) neuroblastoma
Citations Over Time
Abstract
We report a 2.5-month-old infant with bilateral adrenal neuroblastoma, stage 4S(M), with liver metastases and chemotherapy-induced veno-occlusive disease leading to cirrhosis requiring liver transplantation. Despite unknown tumour histology and MYCN-amplification status, we proceeded with liver transplant. This decision was based on clinical suspicion that our patient was MYCN-negative due to significant tumour regression, and was supported by evidence indicating that MYCN-amplification is rare in infants with favourable-stage neuroblastoma. This is the second case report of neuroblastoma requiring liver transplantation; however, in the previously reported case, the diagnosis of neuroblastoma was not established until after transplantation. We discuss this unique case to justify the potential use of life-saving liver transplants in infants with neuroblastoma.
Related Papers
- → Relapsed perinatal neuroblastoma after expectant observation(2014)9 cited
- → Successful liver transplantation in an infant with stage 4S(M) neuroblastoma(2012)11 cited
- → Radioguided localization of neuroblastomas in laparoscopic surgery using 123I‐ radiolabeled metaiodobenzylguanidine(2015)4 cited
- → Neuroblastoma presenting with dilated cardiomyopathy(2006)12 cited
- → Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression(2012)3 cited