Rapid detection of chromosomal aneuploidies in uncultured amniocytes by multiplex ligation-dependent probe amplification (MLPA)
Prenatal Diagnosis2005Vol. 25(11), pp. 1032–1039
Citations Over TimeTop 10% of 2005 papers
Ron Hochstenbach, Judith Meijer, J. van de Brug, I. Vossebeld-Hoff, Renée S. Jansen, Rob B. van der Luijt, Richard J. Sinke, Godelieve C.M.L. Page‐Christiaens, Johannes Kristian Ploos van Amstel, Jennie M. Pater
Abstract
Sensitivity, specificity, and failure rate of MLPA were comparable to those of FISH and QF-PCR. Aneuploidy screening in uncultured amniocytes by MLPA is feasible in a clinical diagnostic setting, yielding an informative and rapid result in 98% of cases.
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