Quantitative chiral analysis of phthaloylglutamic acid and related analogs by a single ratio kinetic method using electrospray ionization and matrix‐assisted laser desorption techniques
Citations Over Time
Abstract
A rapid method for quantitative chiral analysis of phthaloylglutamic acid and its dimethyl ester by Cook's kinetic method is demonstrated using electrospray ionization (ESI) and matrix-assisted laser desorption techniques. Transition-metal-bound complex ions containing the chiral phthaloylglutamic acid and its dimethyl ester are generated by ESI mass spectrometry and subjected to collision-induced dissociation. The ratio of the two competitive dissociation rates is related to the enantiomeric composition of the drug mixture. A seven-point calibration curve, derived from the kinetic method, allowed rapid quantitation of the enantiomeric excess of drug mixtures. In this paper, matrix-assisted laser desorption/ionization (MALDI) coupled with the linear ion trap (LIT) technique is evaluated for its applicability as a complementary technique to ESI for chiral discrimination and quantitation.
Related Papers
- → Matrix‐assisted laser desorption/ionization mechanism study with dihydroxybenzoic acid isomers as matrices(2007)22 cited
- → Infrared-matrix-assisted laser desorption/ionization and infrared-laser desorption/ionization investigations of synthetic polymers(1998)30 cited
- → Evaluation of a new matrix‐free laser desorption/ionization method through statistic studies: comparison of the DIAMS (desorption/ionization on self‐assembled monolayer surface) method with the MALDI and TGFA‐LDI techniques(2008)15 cited
- → Future perspective of nanoparticle interaction‐assisted laser desorption/ionization mass spectrometry for rapid, simple, direct and sensitive detection of microorganisms(2012)
- → Infrared‐matrix‐assisted laser desorption/ionization and infrared‐laser desorption/ionization investigations of synthetic polymers(1998)