Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry
Citations Over TimeTop 19% of 2010 papers
Abstract
Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the present study, we identified nine novel mouse urinary pterostilbene metabolites, pterostilbene glucuronide, pterostilbene sulfate, mono-demethylated pterostilbene glucuronide, mono-demethylated pterostilbene sulfate, mono-hydroxylated pterostilbene, mono-hydroxylated pterostilbene glucuronide, mono-hydroxylated pterostilbene sulfate, and mono-hydroxylated pterostilbene glucuronide sulfate, using liquid chromatography/atmospheric pressure chemical ionization and electrospray ionization tandem mass spectrometry. The structures of these metabolites were confirmed by analyzing the MS(n) (n = 1-3) spectra. To our knowledge, this is the first report of the identification of urinary metabolites of pterostilbene in mice.
Related Papers
- → Metabolism and pharmacokinetics of resveratrol and pterostilbene(2018)286 cited
- → Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease(2011)214 cited
- → Resveratrol, pterostilbene, and dementia(2017)127 cited
- → Lipopolysaccharide Attenuates the Cytotoxicity of Resveratrol in Transformed Mouse Macrophages(2016)4 cited
- → Resveratrol and Pterostilbene Regulate MED28 Expression and Cell Growth in Human Breast Cancer Cells(2015)