Primary hyperaldosteronism caused by adrenocortical carcinoma

Abstract

Abstract Since the syndrome of primary hyperaldosteronism was described by Jerome Conn in 1955, over 300 patients with this disorder have been identified in the medical centers of Vanderbilt University and the University of Michigan. The most frequent cause of this endocrinopathy has been a solitary adenoma of the adrenal cortex (72%); bilateral adrenocortical hyperplasia has been the cause of primary hyperaldosteronism in 27% of cases; less frequently, the cause has been multiple and/or bilateral adenomas (1%). During the last 4 years in these 2 medical centers, we have encountered 3 patients who have had biochemically proven primary hyperaldosteronism due to adrenocortical carcinoma. Each of these unusual cases is summarized with review of the recent literature .

Related Papers

• → Functional Characteristic and Significance of Aldosterone-Producing Cell Clusters in Primary Aldosteronism and Age-Related Hypertension(2021)13 cited
• Malignant aldosterone-producing adrenal tumour: reoccurrence with glucocorticoid excess without hyperaldosteronism.(2008)
• → Primary hyperaldosteronism caused by adrenocortical carcinoma(1986)18 cited
• "Aldosterone escape" or refractory hyperaldosteronism?(2005)
• [Primary hyperaldosteronism due to adrenocortical carcinoma. A clinical case report].(1986)