Aptamer-Based Sensor Arrays for the Detection and Quantitation of Proteins
Analytical Chemistry2004Vol. 76(14), pp. 4066–4075
Citations Over TimeTop 10% of 2004 papers
Romy Kirby, Eun Jeong Cho, Brian Gehrke, Travis Bayer, Yoon Sok Park, Dean P. Neikirk, John T. McDevitt, Andrew D. Ellington
Abstract
Aptamer biosensors have been immobilized on beads, introduced into micromachined chips on the electronic tongue sensor array, and used for the detection and quantitation of proteins. Aptamer chips could detect proteins in both capture and sandwich assay formats. Unlike most protein-based arrays, the aptamer chips could be stripped and reused multiple times. The aptamer chips proved to be useful for screening aptamers from in vitro selection experiments and for sensitively quantitating the biothreat agent ricin.
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