Wound Microenvironment-Responsive Protein Hydrogel Drug-Loaded System with Accelerating Healing and Antibacterial Property
Citations Over TimeTop 10% of 2022 papers
Abstract
Growth factors play a vital role in wound healing, and novel hydrogel carriers suitable for growth factors have always been a research hotspot in the wound healthcare field. In this work, a wound microenvironment-responsive hydrogel drug-loading system was constructed by cross-linking of the internal electron-deficient polyester and bovine serum albumin (BSA) via catalyst-free amino-yne bioconjugation. The slightly acidic microenvironment of wound tissues induces the charge removal of BSA chains, thus releasing the basic fibroblast growth factor (bFGF) loaded through electrostatic action. Besides, the BSA chains in the gel network further endow their excellent biocompatibility and biodegradability, also making them more suitable for bFGF loading. The wound caring evaluation of the hydrogel in the full-thickness skin wound indicated that the protein-based hydrogel significantly promotes the proliferation and differentiation of fibroblasts, collagen accumulation, and epidermal layer stacking, thus significantly shortening the healing process. This strategy paved the way for broadening the application of the growth factors in the wound care field.
Related Papers
- → Construction of Tough, in Situ Forming Double-Network Hydrogels with Good Biocompatibility(2016)81 cited
- → Extracellular vesicles derived from fibroblasts promote wound healing by optimizing fibroblast and endothelial cellular functions(2020)68 cited
- → Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast(2021)30 cited
- → Diversity of Fibroblasts and Their Roles in Wound Healing(2022)59 cited
- → Substances Secreted by Starved Human Dermal Fibroblasts Enhancing the Wound Healing Process in Rat without Scar: A Potential Acellular System for Wound Healing(2016)