Palladium-Catalyzed Acylation/Alkenylation of Aryl Iodide: A Domino Approach Based on the Catellani–Lautens Reaction
ACS Catalysis2015Vol. 5(8), pp. 4927–4931
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Ping‐Xin Zhou, Yu‐Ying Ye, Ce Liu, Lian‐Biao Zhao, Jian‐Ye Hou, Dao-Qian Chen, Qian Tang, Anqi Wang, Jieyu Zhang, Qi‐Xing Huang, Peng‐Fei Xu, Yong‐Min Liang
Abstract
A new palladium-catalyzed three-component coupling involving acylation/alkenylation of aryl iodide is reported. The reaction was carried out with readily available starting materials and gave the ortho-acylated styrene in moderate to good yields. Compared with previous Catellani–Lautens reactions, this reaction is the first example of introducing an acyl group at the ortho position of aryl iodides. The proposed PdIV complex, generated via oxidative addition of the carboxylic anhydrides, is a key intermediate for this transformation.
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