One-Pot Multicomponent Synthesis of Highly Functionalized Piperidines from Substituted β-Nitrostyrenes, Meldrum’s Acid, Aromatic Aldehydes, and Ammonium Acetate
ACS Combinatorial Science2014Vol. 16(3), pp. 113–119
Citations Over TimeTop 19% of 2014 papers
Abstract
An efficient and straightforward synthetic protocol has been developed for the diversity-oriented synthesis of highly functionalized piperidines containing a Meldrum's acid moiety via pseudo five-component reaction between aromatic aldehydes, ammonium acetate, substituted β-nitrostyrenes and Meldrum's acid for the generation of a wide range of structurally interesting and pharmacologically significant compounds.
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