Rapid Synthesis of a Glycosylphosphatidylinositol-Based Malaria Vaccine Using Automated Solid-Phase Oligosaccharide Synthesis
Journal of the American Chemical Society2002Vol. 124(45), pp. 13434–13436
Citations Over TimeTop 10% of 2002 papers
Abstract
Described is an automated synthesis of hexasaccharide malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphatidylinositol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.
Related Papers
- → Advances and challenges in malaria vaccine development(2010)264 cited
- → Progress towards the development of malaria vaccines(2006)47 cited
- Malaria vaccines: triumphs or tribulations?(1999)
- → Workshop report: Malaria vaccine development in Europe–preparing for the future(2015)5 cited
- → Musings on malaria morbidity and mortality after the new Mosquirix® vaccine(2019)2 cited